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PhD position - Experimental research in liver homeostasis
Frankfurt am Main
Aktualität: 12.01.2022

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12.01.2022, Universitätsklinikum Frankfurt
Frankfurt am Main
PhD position - Experimental research in liver homeostasis
The project deals with the role of ER-phagy and hepatoprotection in non-alcoholic steatohepatitis (NASH)-acute-on-chronic liver failure (ACLF) and is part of the LOEWE research consortium "Pathogenic mechanisms of acut-on-chronic liver failure and therapeutic approaches" that started 1.1.2022 in Frankfurt/M. The consortium consists of 14 different projects and three methodological platforms. The work will be carried out in the lab of the Department of Medicine 1 and in the Department of Biochemistry 2 and will be co-directed by Prof. Albrecht Piiper and Prof. Ivan Dikic, with strong background in cellular quality control mechanisms and hepatology. The goal of the project is to identify the role of ER-phagy receptors and cell and tissue protective signaling in mouse models of NASH-ACLF. The successful candidate will take over the transgenic mouse breeding and will plan and perform the experiments, supported by experienced colleagues. Major techniques applied will be transgenic mice, proteomics, RNAseq, FACS, histopathology and fluorescent microscopy.
You have a degree in natural sciences (preferably biology, biochemistry or pharmacy) with specific interest in molecular mechanisms, pathophysiology, medicine and biochemistry. You are used to a careful, structured and independent way of working. You have the ability to work in a team and the motivation to take on responsibility. Your English skills allow you to communicate in an international environment. Due to legal regulations an employment relationship may only be entered by people who are vaccinated against or have recovered from COVID-19. In addition a valid proof of measles immunity / measles vaccination is required.

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PhD position - Experimental research in liver homeostasis

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Frankfurt am Main