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PhD Position - Department of Pediatrics
Frankfurt am Main
Aktualität: 19.03.2024

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19.03.2024, Universitätsklinikum Frankfurt
Frankfurt am Main
PhD Position - Department of Pediatrics
You will work on transcriptional regulation in normal and malignant hematopoiesis. You will define aberrant epigenomic programs that contribute to leukemogenesis. You will identify genes and regulatory sites with a potential role in leukemia via high throughput screening platforms (CRISPR-Cas9 and drug libraries) and validate them using cellular assays in (primary) murine as well as human cells. The aim is to derive and evaluate therapeutic interventions to overcome current obstacles in the treatment of AML using our biobank of patient derived xenografts. These collaborative efforts will investigate the therapeutic potential of targeting aberrant epigenetic networks in AML with projected benefits for patients. You will drive a project that is at the interface of basic molecular biology and translational research. You will perform genome-wide analyses as well as in depth mechanistic studies.
You are a PhD candidate with a master in natural sciences and a strong background in biology and genetics. Knowledge of tissue culture and molecular biology are required. Experience with bioinformatics or at least a strong interest in it is a requirement. Many of the techniques that will be used result in big data sets and so analysis of next generation sequencing data will be a large part of this PhD project. You should be highly motivated, able to work in a team, have good communication skills and be fluent in English (spoken and written). Due to legal regulations, a valid proof of measles immunity / measles vaccination required.

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