Jobs in Forschung, Entwicklung und Naturwissenschaften

At the DKTK partner site Frankfurt/Mainz (work location Department of Hematology and Medical Oncology at the University Medical Center Mainz), an MTA/TA is sought for the DKTK research project «ASTRON». The main task is to carry out experiments (in vitro and 3D bioprints) based on next-generation cellular interventions that can work synergistically with mRNA intervention. The candidate will separately develop interventions and test these in conjunction with mRNA patterns. Cell culture (immune cells, tumor cell lines, but also tissue explants from fresh, healthy or cancer patients, microscopy analysis) CAR/TCR-engineering T cells MRNA interventions within the tumor microenvironment DNA and mRNA preparation, PCR, Western Blotting Functional testing (tumor cell targeting and killing by CAR/TCR-equipped T cells, analysis of T cell metabolic fitness etc.) In vivo oncology/PDX models (mouse studies) Maintenance of in vitro cell lines Administration and documentation (assist with analysis of data, the preparation of research publications and reports, conduct literature searches, and also order lab supplies) Assist in designing and planning research project-related experiments with the group leader Performing laboratory-based research with the requirements of good laboratory practice using a range of techniques, including in immunology, cellular biology, biochemistry and lately in vivo mouse studies